Perhaps the largest factor leading to the decline in Native American populations was

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Disease, particularly smallpox, was the largest factor leading to the decline in Native American populations as they had no immunity to these diseases brought over by European explorers and settlers. This resulted in devastating population losses that in some cases reached 90% or more of the Native American population. While factors such as technology, agriculture, and education certainly played a role in the changes experienced by Native American societies, disease was the primary factor in the catastrophic loss of life.

Perhaps the Largest Factor Leading to the Decline in Native