Which of the following diseases is caused by a peroxisomal defect?

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Zellweger syndrome is caused by a peroxisomal defect, specifically a deficiency in peroxisomal enzymes required for the breakdown of very long-chain fatty acids, phytanic acid, and bile acid intermediates. Sickle-cell anemia is a genetic blood disorder, Tay-Sachs disease is caused by a deficiency in the enzyme hexosaminidase, hypertrophic cardiomyopathy is a heart condition, and I-cell disease is caused by a defect in lysosomal enzyme trafficking.

Which of the Following Diseases Is Caused by a Peroxisomal