Thermogenin and 2,4-dinitrophenol (DNP)are both uncoupling agents. Thermogenin is found in newborn animals and some adult mammals.DNP was marketed in the 1930s as a diet pill.However,DNP treatment not only resulted in weight loss but also death of the patient.Based on this information,how do uncouplers disrupt electron transport/chemiosmosis? Why do thermogenin and DNP result in such different outcomes when both work via a similar mechanism?
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