Citrate is an intermediate in the citric acid cycle,yet it is also an inhibitor of PFK-1.Elevated citrate indicates that the citric acid cycle is blocked so further production of pyruvate is no longer necessary.This is an example of feedback inhibition.

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Elevated citrate acts as an inhibitor of PFK-1, which is an enzyme involved in the glycolysis pathway. This inhibition slows down the glycolytic pathway and reduces the production of pyruvate, which is an intermediate in the pathway. This is an example of feedback inhibition, where the end product of a metabolic pathway acts as an inhibitor of an earlier step to regulate the pathway.

Citrate Is an Intermediate in the Citric Acid Cycle,yet It