A deficiency in thiamine causes the disease beriberi.Which might you expect to have a higher than normal blood concentration in an individual with this condition?
A)Isocitrate.
B)Pyruvate.
C)Oxaloacetate.
D)Acetyl CoA.

Question

Quizplus · Accepted Answer

Thiamine is required for the conversion of pyruvate to acetyl CoA via the pyruvate dehydrogenase complex. A deficiency in thiamine would result in impairment of this process, leading to an accumulation of pyruvate. Thus, an individual with beriberi may have a higher than normal blood concentration of pyruvate.

A Deficiency in Thiamine Causes the Disease Beriberi