Pyruvate dehydrogenase is inactivated by phosphorylation.This can be prevented by a chemical,dichloroacetate,and this disrupts many cancer cells because they are
A)aerobic.
B)anaerobic.
C)fast growing.
D)non-fermenting.

Question

Quizplus · Accepted Answer

Cancer cells often rely on anaerobic glycolysis for energy production, even in the presence of oxygen (Warburg effect). Dichloroacetate inhibits pyruvate dehydrogenase kinase, preventing phosphorylation and inactivation of pyruvate dehydrogenase, thus promoting aerobic metabolism and disrupting the energy production in cancer cells.

Pyruvate Dehydrogenase Is Inactivated by Phosphorylation