While mutation of genes for the biosynthesis of sphingolipids are probably lethal,mutations in genes for the degradation of sphingolipids often lead to metabolic diseases such as Tay-Sachs disease.

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This statement is true. Mutations in genes for the degradation of sphingolipids can lead to metabolic diseases such as Tay-Sachs disease. However, mutations in genes for the biosynthesis of sphingolipids can also lead to various diseases and conditions.

While Mutation of Genes for the Biosynthesis of Sphingolipids Are