A HATS enzymes reacts with the side-chain of lysine to form the following structure: What effect will the HATS enzymes have on histones?
A)No effect,since histones contain few lysine residues.
B)HATS will increase the affinity of histones for DNA.
C)HATS will allow for easier unravelling of histone-DNA structures.
D)HATS activate histones for interaction with mRNA.

Question

A HATS enzymes reacts with the side-chain of lysine to form the following structure: What effect will the HATS enzymes have on histones? 
A)No effect,since histones contain few lysine residues. 
B)HATS will increase the affinity of histones for DNA. 
C)HATS will allow for easier unravelling of histone-DNA structures. 
D)HATS activate histones for interaction with mRNA.

Quizplus · Accepted Answer

The attachment of acetyl groups to lysine residues in histones by HATS enzymes reduces the positive charge on histones, which in turn reduces the attraction between histones and negatively charged DNA. This leads to easier unravelling of histone-DNA structures and allows for better access of transcription factors to the DNA, resulting in increased gene expression. Therefore, the correct choice is C.

A HATS Enzymes Reacts with the Side-Chain of Lysine to Form