________ catalyze the hydrolysis of phosphodiester linkages to release nucleotide residues from only one end of a polynucleotide chain.

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Exonucleases are enzymes that hydrolyze phosphodiester bonds to release nucleotide residues from the ends of a polynucleotide chain. However, they only remove nucleotides from one end of the chain, while endonucleases cleave DNA or RNA at specific sites within the chain. Topoisomerases are enzymes that modify DNA topology, whereas restriction enzymes cleave DNA at specific recognition sequences.

________ Catalyze the Hydrolysis of Phosphodiester Linkages to Release Nucleotide