There are many viruses whose entire genome is Z-DNA.

Question

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Z-DNA is a secondary structure of DNA in which the double helix is formed in a left-handed helical structure instead of the right-handed structure of B-DNA. While there are some regions in DNA that can adopt Z-DNA structure, it is not common for a virus to have its entire genome in this form. Most viruses have genomes composed of either single-stranded RNA or double-stranded DNA that adopts a B-DNA structure.

There Are Many Viruses Whose Entire Genome Is Z-DNA