If there is more globin than heme present in a reticulocyte,globin synthesis is stopped by
A)the activation of HCI (heme-controlled inhibitor).
B)the inactivation of HCI.
C)increasing heme synthesis.
D)decreasing heme synthesis.
E)activating eIF-2.

Question

Quizplus · Accepted Answer

If there is more globin than heme present in a reticulocyte, it indicates that there is a deficiency of heme. This leads to the activation of a protein called Heme-controlled inhibitor (HCI), which stops globin synthesis. The activation of HCI is necessary to prevent the accumulation of globin chains that cannot bind to heme and form functional hemoglobin. Therefore, choice A is the best answer.

If There Is More Globin Than Heme Present in a Reticulocyte,globin