Which equilibrium below applies to noncompetitive inhibition?
A)I
B)II
C)III
D)IV

Question

Which equilibrium below applies to noncompetitive inhibition? 
A)I 
B)II 
C)III 
D)IV

Quizplus · Accepted Answer

In noncompetitive inhibition, the inhibitor can bind to the enzyme at a site other than the active site, causing a change in the enzyme's shape that reduces its activity. This is represented by the equilibrium II, where the inhibitor (I) can bind to either the free enzyme (E) or the enzyme-substrate complex (ES). The binding of the inhibitor does not affect the binding of the substrate, as seen in the constant Km value, but it decreases the maximum velocity (Vmax) of the reaction. Equilibria I, III, and IV represent competitive inhibition, uncompetitive inhibition, and mixed inhibition, respectively.

Which Equilibrium Below Applies to Noncompetitive Inhibition