The intramolecular cyclization reaction of glucose in solution ________.

Question

Quizplus · Accepted Answer

- Generates a chiral center: When glucose cyclizes, a new chiral center is created at the anomeric carbon. This is because the carbonyl group (C=O) and the hydroxyl group (OH) on carbon 5 combine to form a new stereocenter.
- Yields a hemiacetal: The cyclization of glucose forms a hemiacetal, which is a functional group containing both an alcohol (-OH) and an acetal (-OR) group. The hemiacetal group is formed when the carbonyl (C=O) group reacts with an alcohol (-OH) group on the same molecule.
- Usually forms a pyranose: When glucose cyclizes, it can form either a five-membered ring (furanose) or a six-membered ring (pyranose). However, in physiological conditions, glucose almost exclusively forms a six-membered ring, which is called a pyranose.

The Intramolecular Cyclization Reaction of Glucose in Solution ________