Pyranose rings are usually most stable when the ring adopts a ________ conformation with the bulkiest ring substituents in ________ positions.

Question

Quizplus · Accepted Answer

Chair conformation is more stable than boat conformation due to the fewer steric clashes in the former. In addition, the bulkier substituents should occupy the equatorial positions to minimize steric repulsion. Thus, the correct choice is A, chair conformation with the bulkiest ring substituents in equatorial positions.

Pyranose Rings Are Usually Most Stable When the Ring Adopts