Opioids Such as Hydromorphone, Fentanyl, and Meperidine Can Cause Excessive

Opioids such as hydromorphone, fentanyl, and meperidine can cause excessive CNS depression in both the mother and newborn. Opioid antagonists such as naloxone (Narcan) can promptly reverse the CNS depressant effects, especially respiratory depression. The RN should use caution in administering naloxone to opioid dependent women in labor.