The following are important steps in the process of endochondral ossification. What is the correct order for these events?
1) Enlarged chondrocytes die.
2) Osteoblasts replace calcified cartilage with spongy bone.
3) Chondrocytes enlarge and the surrounding matrix begins to calcify.
4) Blood vessels grow around the edges of the cartilage.
5) Perichondrial cells become osteoblasts and produce a superficial layer of bone.
A) 3, 1, 5, 4, 2
B) 1, 3, 5, 4, 2
C) 1, 5, 3, 4, 2
D) 2, 3, 1, 5, 4
E) 3, 1, 4, 5, 2

Question

Quizplus · Accepted Answer

Endochondral ossification begins with chondrocytes enlarging and the matrix calcifying (3), followed by the death of enlarged chondrocytes (1). Blood vessels then grow around the edges of the cartilage (4), perichondrial cells become osteoblasts and produce a superficial layer of bone (5), and finally, osteoblasts replace calcified cartilage with spongy bone (2).

The Following Are Important Steps in the Process of Endochondral