The spontaneous loss of amino groups from adenine results in hypoxanthine, an uncommon base, opposite thymine in DNA. What combination of molecules could repair such damage?
A)nuclease, DNA polymerase, DNA ligase
B)telomerase, primase, DNA polymerase
C)telomerase, helicase, single-strand binding protein
D)DNA ligase, replication fork proteins, adenylyl cyclase
E)nuclease, telomerase, primase

Question

Quizplus · Accepted Answer

The spontaneous loss of amino groups from adenine results in the creation of an abnormal base, hypoxanthine, opposite thymine in DNA. This is commonly repaired by the base excision repair (BER) pathway, which involves the actions of a DNA glycosylase, an AP endonuclease, a DNA polymerase, and a DNA ligase. Therefore, the correct combination of molecules that could repair the damage resulting from the loss of amino groups from adenine would be nuclease (to remove the damaged base), DNA polymerase (to fill the gap with the correct base), and DNA ligase (to seal the nick). Choice A includes all three of these players, making it the best choice.

The Spontaneous Loss of Amino Groups from Adenine Results in Hypoxanthine