Which of the following types of mutation, resulting in an error in the mRNA just after the AUG start of translation, is likely to have the most serious effect on the polypeptide product?
A)a deletion of a codon
B)a deletion of 2 nucleotides
C)a substitution of the third nucleotide in an ACC codon
D)a substitution of the first nucleotide of a GGG codon
E)an insertion of a codon

Question

Quizplus · Accepted Answer

A deletion of 2 nucleotides causes a frameshift mutation, altering the reading frame of the mRNA and potentially changing every amino acid in the polypeptide from that point forward, leading to a significantly altered and likely nonfunctional protein.

Which of the Following Types of Mutation, Resulting in an Error