Sickle-cell disease is probably the result of which kind of mutation?
A)point
B)frameshift
C)nonsense
D)nondisjunction
E)both B and D

Question

Quizplus · Accepted Answer

Sickle-cell disease is caused by a point mutation in the beta-globin gene, resulting in the substitution of one amino acid (glutamic acid) with another (valine). This change in the protein structure causes the red blood cells to become sickle-shaped, leading to various complications. Frameshift, nonsense, and nondisjunction mutations are not known to be associated with sickle-cell disease.

Sickle-Cell Disease Is Probably the Result of Which Kind of Mutation