A few decades ago, Knudsen and colleagues proposed a theory that, for a normal cell to become a cancer cell, a minimum of two genetic changes had to occur in that cell. Knudsen was studying retinoblastoma, a childhood cancer of the eye.
-In colorectal cancer, several genes must be mutated in order to make a cell a cancer cell, supporting Knudsen's hypothesis. Which of the following kinds of genes would you expect to be mutated?
A) genes coding for enzymes that act in the colon
B) genes involved in control of the cell cycle
C) genes that are especially susceptible to mutation
D) the same genes that Knudsen identified as associated with retinoblastoma
E) the genes of the bacteria that are abundant in the colon

Question

Quizplus · Accepted Answer

According to Knudsen's hypothesis, mutations in genes involved in control of the cell cycle are required for a normal cell to become a cancer cell. Thus, in colorectal cancer, one would expect to see mutations in genes that regulate the cell cycle.

A Few Decades Ago, Knudsen and Colleagues Proposed a Theory