The Major Advantage of Using Artificial Chromosomes Such as YACs

The major advantage of using artificial chromosomes such as YACs and BACs for cloning genes is that

A) plasmids are unable to replicate in cells.
B) only one copy of a plasmid can be present in any given cell, whereas many copies of a YAC or BAC can coexist in a single cell.
C) YACs and BACs can carry much larger DNA fragments than ordinary plasmids can.
D) YACs and BACs can be used to express proteins encoded by inserted genes, but plasmids cannot.
E) all of the above