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HIV's genome of RNA includes code for reverse transcriptase (RT), an enzyme that acts early in infection to synthesize a DNA genome off of an RNA template. The HIV genome also codes for protease (PR), an enzyme that acts later in infection by cutting long viral polyproteins into smaller, functional proteins. Both RT and PR represent potential targets for antiretroviral drugs. Drugs called nucleoside analogs (NA) act against RT, whereas drugs called protease inhibitors (PI) act against PR.
-HIV has 9 genes in its RNA genome. Every HIV particle contains two RNA molecules, each molecule containing all 9 genes. If, for some reason, the two RNA molecules within a single HIV particle do not have identical sequences, then which of these terms can be applied due to the existence of the non-identical regions?

Question

Quizplus · Accepted Answer

The presence of non-identical sequences in the RNA molecules of an HIV particle indicates variability at the nucleotide level, which can be described by terms like gene variability and nucleotide variability. Average heterozygosity is also a measure of genetic variation, so all options except homozygous (which implies identical sequences) are applicable.

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