A genetic change that caused a certain Hox gene to be expressed along the tip of a vertebrate limb bud instead of farther back helped to make possible the evolution of the tetrapod limb. This type of change is illustrative of

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This genetic change is a clear example of a change in a developmental gene or its regulation that resulted in a modification in the spatial organization of body parts, in this case, the development of a limb. This is known as heterotopy, which refers to a mutation that changes the location of gene expression within an organism's developmental program.

A Genetic Change That Caused a Certain Hox Gene to Be