Which mutation should least require realignment of homologous regions of a gene that is common to several related species?
A)3-base insertion
B)1-base substitution
C)4-base insertion
D)1-base deletion
E)3-base deletion

Question

Quizplus · Accepted Answer

A one-base substitution may cause a change in the amino acid sequence, but it would not cause a shift in the reading frame or require realignment of homologous regions. Insertions and deletions would cause a frameshift, which would require realignment of the homologous regions. The larger the insertion or deletion, the more challenging it would be to realign the homologous regions.

Which Mutation Should Least Require Realignment of Homologous Regions of a Gene