Which of the Following Is (Are)True

Which of the following is (are) True?

A) Hormones regulate cellular functions, and generally negative feedback regulates hormone levels.
B) The circulating level of a hormone is held constant through a series of positive feedback loops.
C) Both lipid-soluble hormones and water-soluble hormones bind to intracellular protein receptors.
D) The ducts of endocrine organs release their contents into the bloodstream.
E) Only A and C are True.