Which side effect of clindamycin [Cleocin] causes the most concern and may warrant discontinuation of the drug?

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CDAD is a serious, sometimes fatal suprainfection associated with clindamycin. Patients with diarrhea should notify their prescriber immediately and discontinue the drug until this condition has been ruled out. Headache, nausea, and vomiting do not warrant discontinuation of the drug and are not associated with severe side effects.

Which Side Effect of Clindamycin [Cleocin] Causes the Most Concern