When teaching the patient who is receiving standard multidrug therapy for tuberculosis ( TB ) about possible toxic effects of the antitubercular medications, the nurse will give instructions to notify the health care provider if the patient develops

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Noninfectious hepatitis is a toxic effect of isoniazid (INH), rifampin, and pyrazinamide, and patients who develop hepatotoxicity will need to use other medications. Changes in hearing and nail thickening are not expected with the four medications used for initial TB drug therapy. Orange discoloration of body fluids is an expected side effect of rifampin and not an indication to call the health care provider.

When Teaching the Patient Who Is Receiving Standard Multidrug Therapy