Why May Gastrointestinal (GI)bleeding and Ulcers Occur from Taking Aspirin

Why may gastrointestinal (GI) bleeding and ulcers occur from taking aspirin or NSAIDs?

A) The drugs are metabolized in the stomach causing additional acid in the stomach and potentially creating an ulcer and then bleeding.
B) Because cyclooxygenase is an important part of the immune system,the blockade created inhibits the body from defending itself.
C) Platelet aggregation is reduced due to cyclooxygenase blockade,which increases bleeding in the body.
D) The GI lining loses some of its protection because aspirin and NSAIDs inhibit cyclooxygenase action,thereby decreasing prostaglandin synthesis.