In the U.S., the leading cause of death (total number of all deaths in a year) is

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According to the Centers for Disease Control and Prevention (CDC), heart disease is the leading cause of death in the United States, accounting for nearly 650,000 deaths per year. Cancer is the second leading cause with just over 600,000 deaths, followed by accidents and chronic lower respiratory disease. Stroke and diabetes are also among the top 10 leading causes of death but not as high as heart disease and cancer.

In the US, the Leading Cause of Death (Total Number of All