European colonization of the New World resulted in the greatest loss of human life in history.The primary factor responsible was

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European colonization brought diseases like smallpox, influenza, and measles to the New World, which the indigenous people had no immunity to. This resulted in a massive loss of life, decimating the population by an estimated 90-95%. War, slavery, natural disasters, and famine also played a role, but none were as significant as diseases.

European Colonization of the New World Resulted in the Greatest