A Patient Has a Prescription for Topically Applied 5% Fluorouracil

A patient has a prescription for topically applied 5% fluorouracil (Efudex) cream as part of treatment for basal cell carcinoma on her cheek. Which instructions will the nurse provide to the patient? (Select all that apply.)

A) "You must use gloves to apply this medication."
B) "You can use clean fingertips to apply the cream, but be sure to wash your hands afterward."
C) "You will need to stay out of the sun during therapy with this medication."
D) "Apply this medication to the affected site once a day in the evening."
E) "Apply this medication to the affected site twice daily."
F) "You may have swelling, scaling, burning, and tenderness in the affected area."