Which of the following is an adverse drug interaction that may occur if a dental anesthetic containing a vasoconstrictor is administered to a patient being treated for hypertension with a non-selective β-adrenergic blocking agent?

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Quizplus · Accepted Answer

The basis for concern with use of non-selective β-adrenergic blocking agents (e.g.,propranolol)is that the normal compensatory vasodilation of skeletal muscle vasculature mediated by beta 2 receptors is inhibited by these drugs,and injection of epinephrine,levonordefrin,or any other pressor agent may result in uncompensated peripheral vasoconstriction because of unopposed stimulation of alpha 1 receptors.This vasoconstrictive effect could potentially cause a significant elevation in blood pressure and a compensatory bradycardia.

Which of the Following Is an Adverse Drug Interaction That