Tachyphylaxis Is a Term Used to Describe What Phenomenon

Tachyphylaxis is a term used to describe what phenomenon?

A) An increased tolerance to a drug that is administered repeatedly.
B) If the dental procedure lasts longer than the duration of the anesthetic and the mantel and core fibers have fully recovered, the reinjection of local anesthetic will be ineffective.
C) Once the mantel fibers return to function, the patient experiences pain yet administration of anesthetic does not alleviate the pain.
D) All of the above