Under What Conditions Might the Risks of Using a Local

Under what conditions might the risks of using a local anesthetic with a vasoconstrictor outweigh the benefits?
1) A medically compromised patient
2) A patient with unstable angina or uncontrolled hypertension
3) A patient with a recent knee replacement
4) A patient with severe gingivitis and perio
5) A patient with uncontrolled diabetes

A) Some other combination
B) 2, 4
C) 1, 2, 5
D) 1, 4, 5
E) All of the above