The dopamine hypothesis suggests that a depletion of dopaminergic transmission contributes to the onset of schizophrenia.

Question

Quizplus · Accepted Answer

In the dorsal prefrontal cortex of schizophrenic brains, glutamic acid decarboxylase, the major enzyme in gamma-aminobutyric acid (GABA) biosynthesis, is diminished, which likely impairs synaptic performance and cognitive and behavioral functions associated with this brain region. Dopamine transmission does not play a primary role in the onset of schizophrenia.

The Dopamine Hypothesis Suggests That a Depletion of Dopaminergic Transmission