In beta-thalassemia major, most erythroblasts are destroyed in the spleen.

Name: In beta-thalassemia major, most erythroblasts are destroyed in the spleen.
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Depression of β-chain synthesis results in erythrocytes having a reduced amount of hemoglobin and accumulations of free α-chains. The free a-chains are unstable and easily precipitate in the cell. Most erythroblasts that contain precipitates are destroyed by mononuclear phagocytes in the marrow, resulting in ineffective erythropoiesis and anemia.

In Beta-Thalassemia Major, Most Erythroblasts Are Destroyed in the Spleen