Hemoglobin S (Hb S) Is Formed in Sickle Cell Disease

Hemoglobin S (Hb S) is formed in sickle cell disease as a result of a(n) :

A) deficiency in G6PD that changes Hb A to Hb S.
B) genetic mutation in which two amino acids (histidine and leucine) are missing.
C) genetic mutation in which one amino acid (valine) is replaced by another (glutamic acid) .
D) autoimmune response in which one amino acid (proline) is detected as an antigen by abnormal IgG.