Which T lymphocyte phenotype is the key determinant of childhood asthma?
A)CD4 T-helper Th1 lymphocytes
B)CD4 T-helper Th2 lymphocytes
C)CD8 cytotoxic T lymphocytes
D)Memory T lymphocytes

Question

Quizplus · Accepted Answer

Asthma develops because the Th₂ response (in which CD4 helper T cells [Th] produce specific cytokines, such as IL-4, IL-5, and IL-13) promotes an atopic/allergic response in the airways as opposed to a Th₁ response characteristic of delayed-type hypersensitivity and phagocyte-mediated host defense. IL-4 and IL-13 are particularly important for B-cell switching to favor IgE production, and IL-5 is crucial for local differentiation and enhanced survival of eosinophils within the airways.

Which T Lymphocyte Phenotype Is the Key Determinant of Childhood