Considering the pathophysiology of osteoporosis, what are the effects of extracellular signal regulated kinases (ERKs) and receptor activator of RANKL on osteoblasts and osteoclasts?
A)ERKs increase the life span of osteoclasts and RANKL decreases the life span of osteoblasts.
B)ERKs and RANKL increase the life span of osteoclasts and decrease the life span of osteoblasts.
C)ERKs and RANKL increase the life span of osteoblasts and decrease the life span of osteoclasts.
D)ERKs increase the life span of osteoblasts and RANKL decreases the life span of osteoclasts.

Question

Quizplus · Accepted Answer

In addition to ERKs, RANKL is required for the antiapoptotic and thus longer life span of osteoclasts. These effects increase the life span of osteoclasts (i.e., longer bone resorbing) and shorten the life span of the bone-forming cells, or osteoblasts.

Considering the Pathophysiology of Osteoporosis, What Are the Effects of Extracellular