What stimulates the "respiratory burst" and production of highly toxic free radicals in MODS?

Question

Quizplus · Accepted Answer

The accumulation of activated neutrophils in organs is thought to play a key role in the pathogenesis of MODS. When neutrophils adhere to the endothelium, they undergo a "respiratory burst" (oxidative burst) and release oxygen radicals. The respiratory burst occurs as the activated neutrophil experiences a sudden increase in oxidative metabolism, producing large quantities of highly toxic oxygen free radicals.

What Stimulates the "Respiratory Burst" and Production of Highly Toxic