By blocking the effect of acetylcholine at muscarinic but not nicotinic receptors, atropine is able to block parasympathetic effects.

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Atropine is a muscarinic receptor antagonist, meaning it blocks the effects of acetylcholine at muscarinic receptors in the parasympathetic nervous system, but does not affect nicotinic receptors found in both the sympathetic and parasympathetic nervous systems. This results in the blocking of parasympathetic effects, such as decreased heart rate and increased gastrointestinal motility.

By Blocking the Effect of Acetylcholine at Muscarinic but Not