Which of the following decreases Hb's affinity for oxygen?
A)increased blood pH
B)low partial pressure for CO₂
C)high BPG
D)high partial pressure for O₂
E)decreased concentration of H+

Question

Quizplus · Accepted Answer

High levels of 2,3-bisphosphoglycerate (BPG) are known to decrease Hb's affinity for oxygen by binding to the central cavity of Hb, causing a conformational change that stabilizes the T state, and thus reducing the ability of Hb to bind oxygen.

Which of the Following Decreases Hb's Affinity for Oxygen