Hypertonicity in the ECF is sensed by osmoreceptors in the hypothalamus.

Question

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Osmoreceptors in the hypothalamus are sensitive to changes in osmolality (concentration) of the extracellular fluid (ECF). When the ECF becomes hypertonic, meaning there is a high concentration of solutes (such as salt or glucose), the osmoreceptors are activated and trigger the release of anti-diuretic hormone (ADH) to increase water reabsorption in the kidneys and restore fluid balance.

Hypertonicity in the ECF Is Sensed by Osmoreceptors in the Hypothalamus