After pepsinogen is activated, it
A)autocatalytically activates more pepsinogen
B)activates pancreatic enzymes in the duodenum after gastric emptying has occurred
C)inhibits the pyloric gland area in a negative-feedback fashion
D)does a and b
E)does none of the above

Question

Quizplus · Accepted Answer

Pepsinogen is activated by hydrochloric acid in the stomach and converted into pepsin, which is an enzyme that breaks down proteins into smaller peptides. Once pepsinogen is activated into pepsin, it can autocatalytically activate more pepsinogen, thereby creating a positive feedback loop of pepsin production. Option B is incorrect because activated pepsin does not activate pancreatic enzymes, but rather, it helps to initiate protein digestion in the stomach. Option C is also incorrect as there is no evidence that activated pepsin inhibits the pyloric gland area in a negative-feedback fashion.

After Pepsinogen Is Activated, It