One of the hormones involved in a specific endocrine axis must pass through the hypothalamic-hypophyseal portal system.

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The hypothalamic-hypophyseal portal system is a specialized system of blood vessels that allows hormones produced by the hypothalamus to be transported directly to the anterior pituitary gland. This is necessary for the regulation of several endocrine axes, such as the hypothalamic-pituitary-adrenal axis and the hypothalamic-pituitary-gonadal axis. Hormones that are part of these axes, including corticotropin-releasing hormone (CRH), luteinizing hormone-releasing hormone (LHRH), and follicle-stimulating hormone-releasing hormone (FSHRH), must pass through the hypothalamic-hypophyseal portal system to reach their target cells in the anterior pituitary gland.

One of the Hormones Involved in a Specific Endocrine Axis