Which of the Following Statements Accurately Describes Hormonal Signaling, as Depicted

Which of the following statements accurately describes hormonal signaling, as depicted in this figure?

A) Each endocrine cell has the ability to make all of an organism's hormones.
B) Hormones act on specific target cells.
C) Hormones may diffuse into the circulatory system but they cannot diffuse out of it.
D) Target cells signal each other using hormones.