The macula densa cells respond to ________.
A) aldosterone
B) antidiuretic hormone
C) changes in pressure in the tubule
D) changes in solute content of the filtrate

Question

Quizplus · Accepted Answer

Macula densa cells are specialized cells in the distal tubule of the kidney that respond to changes in solute content of the filtrate, particularly sodium chloride. When the concentration of sodium chloride in the filtrate is high, the macula densa cells stimulate the juxtaglomerular cells to secrete renin, which initiates the renin-angiotensin-aldosterone system to regulate blood pressure and fluid balance. Therefore, choice D, changes in solute content of the filtrate, is the best answer.

The Macula Densa Cells Respond to ________