The replacement of red bone marrow with yellow bone marrow in the limbs occurs

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The replacement of red bone marrow with yellow bone marrow in the limbs occurs between 8 and 18 years of age. During childhood, a significant amount of red bone marrow is gradually replaced with yellow adipose tissue, especially in the long bones, as the body shifts from hematopoiesis in bone marrow to hematopoiesis primarily in the pelvis, vertebrae, and cranium. By early adulthood, most of the red bone marrow in the limbs has been replaced with yellow adipose tissue.

The Replacement of Red Bone Marrow with Yellow Bone Marrow