Elevated concentrations of potassium in the ECF can occur when hemolysis of red blood cells increases, such as with leukocytosis or thrombocytosis.

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Hemolysis of red blood cells releases intracellular potassium into the extracellular fluid (ECF), which can lead to elevated concentrations of potassium in the ECF. Conditions that increase hemolysis, such as leukocytosis or thrombocytosis, can therefore contribute to hyperkalemia.

Elevated Concentrations of Potassium in the ECF Can Occur When