Long-term use of St. John's wort may result in diminished clinical effectiveness or increased dosage requirements for at least what percentage of all marketed medications?

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St. John's wort is known to induce enzymes that metabolize drugs, thus reducing the level of the drug in the body and decreasing its effectiveness. This effect can occur in up to 50% of all marketed medications, including some antibiotics, immunosuppressants, antidepressants, and birth control pills. It is important for healthcare providers and patients to be aware of this interaction and monitor medication effectiveness when using St. John's wort long-term.

Long-Term Use of St